Difference Between Cyclosporine and Tacrolimus

Definition

Cyclosporine refers to a drug with immunosuppressive properties used to prevent the rejection of grafts and transplants while tacrolimus refers to a calcineurin inhibitor used to prevent organ transplant rejection and to treat moderate to severe atopic dermatitis.

Structure

Cyclosporine is a cyclic endecapeptide while tacrolimus is a macrocyclic lactone.

Significance

Cyclosporine is more cost-effective as the primary prevention of graft rejection while tacrolimus is effective and safe as an immunosuppressant.

Adverse Effects

Cyclosporine increases the risk of hypertension and the levels of LDL while tacrolimus increases posttransplant diabetes and neurologic toxicity.